Endocrine Abstracts

Background: A testicular adrenal rest tumor in an adult males who complaint with testicular enlargement and fertility request, and diagnosed with congenital adrenal hyperplasia due to 11-beta hydroxylase deficiency with homozygous mutation L299P in the CYP11B1 gene and accompanied by impaired spermatogenesis and Leydig cell failure was reported.Case Report: A 27-year-old man was complaint with bilateral progressive painful enlargement of the testes, cont...

LCH is a rare proliferative histiocytic disorder, and it can infiltrate virtually any site in the body. Diabetes incipidus (DI) is the most common abnormality when there is involvement of the hypothalamic-pituitary axis (HPA). We have evaluated the anterior pituitary function and their responses to treatment in 9 patients (5M/4F; range 19–60 years) with proven LCH and DI. Endocrine evaluations consisted of clinical history, basal (GH, IGF-1, fT4, TSH, PRL, cortisol, LH, F...

Introduction: The aim of this study was to evaluate the worth of the salivary cortisol after overnight 1 mg dexamethasone suppression test (DST) in different patients.Materials and methods: The patient groups of the study consisted of 18 Cushing’s syndrome patients, 12 patients with non-functional adrenal incidentaloma, 37 patients with obesity, 16 patients with hirsutism and 26 healthy control patients. Salivary cortisol (SC) and plasma cortisol af...

Introduction: Currently, about 5–15% of non-medullary thyroid cancers (FNMTC) are considered to be of familial origin. These are either syndrome-associated tumours or non-syndromic tumours. The aim of the study was to determine the clinical, pathological and biochemical characteristics of FNMTC compared to non-familial ones with a follow-up of 10 years.Methods: Among FNMCT followed by a single physician, 62 patients with papillary cancer were screen...

Introduction: Fibroblast growth factor (FGF)-23 is a peptid, released from bone tissue and osteogenic cells. Phosphatonins regulate phosphate homeostasis in some phosphate wasting disorders such as X-linked hypophosphatemia, otozomal dominant hypophosphatemic rickets, and tumor-induced osteomalacia.FGF-23 is a possible phosphatonin: it regulates phosphate homeostasis by PTH independent actions.Objective: In the present study, we ai...

Primary hyperparathyroidism (PHP) during pregnancy is a very rare event that increases maternal and fetal morbidity and mortality. Complications during pregnancy or neonatal period have included spontaneous abortion, stillbirth, neonatal death, neonatal tetany.Management of maternal PHP diagnosed during pregnancy should be based on the patients’ symptoms and severity of the disease. Hyperparathyroidism characterized by progressive symptoms should be...

Ectopic ACTH syndrome (EAS) occurs in around 10% of all cases with ACTH-dependent hypercortisolism. The mean age of clinical presentation varies from 45 to 50 years, and most of them caused by intrathoracic neoplasm, and recognition of the disorder may be delay. Subsequently, it may be difficult to locate the ACTH source and manage the patients’ hypercortisolism. We present our patients with EAS from 2000 to 2007. Four patients, aged 15–43 years, two females and two ...

Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by decreased responsiveness of target tissues to thyroid hormone. Two members of a Turkish family, a mother and son, had thyroid function tests suggestive of resistance to thyroid hormone (RTH).Methods: The clinical presentation was, however, different. The mother (proposita) had palpitation, weakness, tiredness, nervousness, dry mouth and was misdiagnosed as...

Objective: We aimed to investigate the expression of ret/PTC oncogene in PTC and to determine the relationship of this expression with clinical parameters and the prognosis.Materials and methods: Surgical specimens of 45 PTC and adjacent normal thyroid tissues were obtained from the files of the Department of Pathology at Istanbul Faculty of Medicine, Istanbul University. All of the patients had definite diagnosis of PTC between 1995–2003 and had ad...

Background: Functional and morphological changes of endothelium are risk factors for mortality attributed to atherosclerosis. Studies investigating early atherosclerotic alterations and the effect of the treatment of acromegaly on these alterations gave conflicting results.Objective: Surrogate markers of early atheosclerotic changes, i.e. brachial artery flow-mediated dilation (FMD) and carotid artery intima-media-thickness (IMT) in active and inactive a...